Stevens-Johnson syndrome and toxic epidermal necrolysis: case series and brief literature review
Tatevik Aloyan 1,*, Zaruhi Kalikyan 2, Sona Harutyunyan 2, Alexandra Zakaryan 2, Mariam Movsisyan 2, Lusntag Ktsoyan 2, Ovanes Karslyan 3, Armine Hakobyan 1,2
1 Allergy and Immunology Clinics, Heratsi N1 University Hospital Complex, Yerevan, Armenia
2 Department of Clinical Immunology and Allergy, Heratsi Yerevan State Medical University, Yerevan, Armenia
3 Department of Traumatology and Orthopedic Surgery, Avdalbekyan National Institute of Health, Yerevan, Armenia
ABSTRACT
Stevens-Johnson syndrome (SJS) and toxic epi- dermal necrolysis (TEN) are rare forms of delayed-type drug hypersensitivity reactions (DHRs) with extensive skin necrosis and exfoliation. Drugs are the main cause of SJS and TEN in both adults and children. The most common medications are allopurinol, aromatic antiepileptics and sulfonamides with seasonal, geographical and ethnic variations. The purpose of this paper is to present the cases of SJS/TEN which were successfully treated during the year of 2021 in our department and to provide a brief literature review.
Keywords: drug allergy, drug hypersensitivity reactions, Stevens-Johnson syndrome