Extracorporeal Hemocorrection and Photohemotherapy as Components of Treatment of a Patient With Exacerbation of Familial Mediterranean Fever: Clinical Observation
Perov Օ., Larichev S., Khosrovyan A., Ostapchenko D., Perov D., Danielyan S.
1. Hospital for War Veterans Moscow, Russia
2. Skobelkin Scientific and Practical Center of Laser Medicine, Moscow, Russia
3. Pirogov Clinical Hospital No. ١, Moscow, Russia
4. Medical College No. ٥, Moscow, Russia
ABSTRACT
Familial Mediterranean fever (FMF) is one of the congenital monogenic autoinflammatory diseases. The cause of its development is an inherited defect in various parts of the MEFV gene, resulting in an altered structure of the pyrin protein, which loses its regulatory influence on cell inflammasomes, ultimately leading to immune cell death – pyroptosis, accompanied by a local and systemic inflammatory response. We presented an example of successful treatment of a patient with exacerbation of FMF after military trauma, with limitations to pathogenetic therapy with colchicine, which was treated with sessions of plasmapheresis and intravenous laser irradiation of blood to control the inflammatory response.
Keywords: familial Mediterranean fever, colchicine, plasmapheresis, intravenous laser irradiation of blood