Mediastinal “gray” zone lymphoma: cases from Armenia
Ghahramanyan N.,1,2 Harutyunyan L.,1,2 Oganesyan A.,3 Hakobyan Ye.1-3
1 Yolyan Hematological Center, Yerevan, Armenia
2 Armenian Hematological Association, Yerevan, Armenia
3 Department of Hematology and Transfusion Medicine, Avdalbekyan National Institute of Health, Yerevan, Armenia
ABSTRACT
“Gray” zone lymphoma (GZL), a B-cell lymphoma with features intermediate between large B-cell lymphoma (LBCL) and classic Hodgkin lymphoma (cHL), is a rare, recently recognized and poorly defined entity. It is recognized now that GZL may present clinically with primary mediastinal type (MGZL) or systemic disease without mediastinal involvement. Regardless of clinical presentation, patients with GZL have relatively high relapse rates, especially compared with primary mediastinal DLBCL or cHL, and the optimal treatment approach of this disease is unknown yet. We present case descriptions of GZL diagnosed in Armenia.
Keywords: lymphoma, gray zone, mediastinum, Armenia