The role of FSHR genes in the development of endometriosis: research opportunities in uzbekistan
Arthur Karamanian1, Zhanna Pakhomova2
¹Mediofarm Hospital Clinic
²Tashkent Medical Academy (Tashkent, Uzbekistan)
Abstract
Endometriosis is a chronic condition affecting a significant number of women of reproductive age and is characterized by the presence of endometrial-like tissue outside the uterus. This article explores the role of follicle-stimulating hormone receptor (FSHR) genes in the pathogenesis of endometriosis and the feasibility of conducting related studies in Uzbekistan. The FSHR gene encodes a receptor that mediates the action of follicle-stimulating hormone, which plays a key role in regulating the menstrual cycle and ovulation. Dysregulation of FSHR function may contribute to the development of various reproductive disorders, including endometriosis.
Studies suggest that polymorphisms in the FSHR gene may be associated with an increased risk of developing endometriosis. In particular, analysis of FSHR expression levels in endometriotic tissue revealed a significant increase compared to normal endometrium. The polymerase chain reaction (PCR) method is an effective tool for studying polymorphisms and expression levels of genes associated with endometriosis.
Uzbekistan has the necessary resources and potential to conduct such research, which may improve the diagnosis and treatment of this condition. Establishing collaborations between medical institutions, research centers, and educational institutions will be a key factor in advancing scientific research in the field of endometriosis. Such studies not only contribute to understanding the pathogenesis of the disease but can also enhance the quality of life for women suffering from endometriosis by introducing new diagnostic and therapeutic approach.