Efficacy and safety of HPV vaccine: a review of the literature
Vahe Ter-Minasyan1,*, Vadim Frolov2, Gagik Bazikyan1, Vahan Manvelyan1, Hripsime Mokatsyan1, Ara Drampyan1, Hayk Melkumyan
¹ National Institute of Health (Yerevan, Armenia)
² “Astghik” Medical Center (Yerevan, Armenia)
Abstract
We have undertaken a generalized presentation of data on aspects of the effectiveness and safety of various HPV vaccination measures available in the English-language literature. The review includes 50 sources (5 of which are systematic reviews) published over the past 10 years. The selection was made by matching the subjects of the studies to current concepts of HPV infection control and including all the predefined keywords. The data studied included reports and recommendations of the WHO, health authorities of European countries and USA, the results of observational studies and clinical trials studying the effectiveness of different vaccinations programs, as well as systematic reviews. The core part of the review presents data published by WHO and special task forces of US preventive services, as well as the authors of multi-center studies in European countries, devoted to a comparative analysis of the effectiveness of various vaccination programs in countries with different income levels. The analysis attempts to highlight efficacy of HPV vaccine and its safety issues. The reviewed provides the basis and motivational framework to analyze the clinical efficacy, safety and cost efficacy of the vaccine used in RA. The subsequent implementation of community based study will contribute to the adequate evaluation of the anti-HPV vaccination program in RA as a primary prevention measure for cervical cancer.
Keywords։ HPV, vaccination, papillomavirus, vaccination efficacy, safety